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Monday, April 27, 2020 | History

2 edition of Evaluation of a subunit vaccine to infectious hematopoietic necrosis virus found in the catalog.

Evaluation of a subunit vaccine to infectious hematopoietic necrosis virus

JoAnn Ching Leong

Evaluation of a subunit vaccine to infectious hematopoietic necrosis virus

final project report

by JoAnn Ching Leong

  • 273 Want to read
  • 36 Currently reading

Published by U.S. Dept. of Energy, Bonneville Power Administration, Division of Fish & Wildlife in Portland, Or .
Written in English

    Subjects:
  • Salmon -- Diseases.,
  • Steelhead (Fish) -- Diseases.,
  • Viral vaccines.,
  • Fishes -- Diseases.

  • Edition Notes

    Statementprepared by Jo-Ann C. Leong.
    ContributionsUnited States. Bonneville Power Administration. Division of Fish and Wildlife.
    The Physical Object
    Paginationii, 132 p. :
    Number of Pages132
    ID Numbers
    Open LibraryOL15565033M

      Caple J. Varicella-zoster virus vaccine: a review of its use in the prevention of herpes zoster in older adults. Drugs Today (Barc). Apr. 42(4) van Hoek AJ, Gay N, Melegaro A, Opstelten W, Edmunds WJ. Estimating the cost-effectiveness of vaccination against herpes zoster in England and Wales. Vaccine. Feb 27(9) A novel, gene-based investigational vaccine protected mice and monkeys against Zika virus infection after a single dose, according to a study appearing online in the journal Nature on Feb. 2. The research was conducted by investigators funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), NIAID scientists, . Study to Evaluate the Immunogenicity and Safety of an Ebola Virus (EBOV) Glycoprotein (GP) Vaccine in Healthy Subjects. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Other approaches under investigation might also provide good results, including subunit vaccine, plasma DNA vaccine, and infectious cloned vaccine (e.g., chimeric dengue-4 backbone), and recombinant dengue vaccine containing NS-1 (which is a potent antigen in experimental vaccines against yellow fever).


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Evaluation of a subunit vaccine to infectious hematopoietic necrosis virus by JoAnn Ching Leong Download PDF EPUB FB2

Evaluation of a Subunit Vaccine to Infectious Hematopoietic Necrosis Virus, J to Septem Annual Report. Showing of 59 pages in this report. PDF Version Also Available for Download.

Description. A recombinant DNA vaccine to IHNV was prepared and tested in field trials at Clear Springs Trout Company's Box Canyon Author: JoAnn Ching Leong. Infectious hematopoietic necrosis virus (IHNV), is a negative-sense single-stranded, bullet-shaped RNA virus that is a member of the Rhabdoviridae family, and from the genus causes the disease known as infectious hematopoietic necrosis in salmonid fish such as trout and disease may be referred to by a number of other names such as Chinook salmon Family: Rhabdoviridae.

The DNA vaccine pIHNw-G encodes the glycoprotein of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV). Vaccine performance in rainbow trout was measured 3, 6, 13, 24, and   Hepatitis E virus (HEV) of the family Hepeviridae 1 is an important viral pathogen causing enterically-transmitted non-A, non-B viral hepatitis year HEVs cause approximately 20 million infections globally, resulting in around 3 million acute cases of hepatitis E and claim lives rus (RV) and astrovirus (AstV), members of the families of Cited by: Evaluation of dual nasal delivery of infectious hematopoietic necrosis virus and enteric red mouth vaccines in rainbow trout (Oncorhynchus mykiss) Article in.

In structural biology, a protein subunit is a single protein molecule that assembles (or "coassembles") with other protein molecules to form a protein naturally occurring proteins have a relatively small number of subunits and therefore described as oligomeric, for example hemoglobin or DNA may consist of a very large number of.

Administered by intramuscular injection, a DNA vaccine (pIRF1A-G) containing the promoter regions upstream of the rainbow trout interferon regulatory factor 1A gene (IRF1A) driven the expression of the infectious hematopoietic necrosis virus (IHNV) glycoprotein (G) elicited protective immune responses in rainbow trout (Oncorhynchus mykiss).However, less laborious Cited by: 1.

Introduction. Infectious hematopoietic necrosis virus (IHNV) is a member of the Novirhabdovirus genus in the Rhabdoviridae family [].IHNV is regarded as one of the most significant threats to the salmonid farming industry by: 5. How to cite this article: Xia, M. et al. Development and evaluation of two subunit vaccine candidates containing antigens of hepatitis E virus, rotavirus, and astrovirus.

Sci. Rep. 6, Cited by: Infectious Hematopoietic Necrosis Virus (IHNV) I. Causative Agent and Disease III. Clinical Signs.

Infectious hematopoietic necro-sis virus (IHNV) is a bullet-shaped novirhabdovirus that is enzootic to the North American Pacific Northwest but was inadvertently established in the US Snake River Valley in Idaho and in sev.

Recombinant vaccines against infectious hematopoietic necrosis virus: either through the expression of a fragment of the IHNV glycoprotein or by carrying a plasmid DNA vaccine encoding the complete IHNV glycoprotein.

A cell wall deficient strain (Δdap) protected rainbow trout against lethal challenge with pathogenic Y. ruckeri. Author: Benjamin E. Simon. This article reviews some of the recent patents on DNA vaccines against fish viruses, in particular against the novirhabdovirus infectious hematopoitic necrosis virus (IHNV).

Although very effective in protecting fish against IHNV, only one DNA vaccine has been approved to date for use in by: The DNA vaccine, pIHNVw-G, contains the gene for the glycoprotein (G) of the rhabdovirus infectious hematopoietic necrosis virus (IHNV), a major pathogen of salmon and trout.

The relative efficacy of various routes of immunisation with pIHNVw-G was evaluated using g rainbow trout fry vaccinated via intramuscular injection, scarification of the skin, intraperitoneal injection, Cited by: Infectious Hematopoietic Necrosis is a viral disease that infects salmon and trout of all age classes, but severe losses primarily occur in young fish.

The virus attacks the blood forming tissues of the fish, the kidney and spleen, and currently there. @article{osti_, title = {Cloning, sequence, and expression of the glycoprotein gene of infectious hematopoietic necrosis virus, a fish rhabdovirus}, author = {Feyereisen-Koener, J.M.}, abstractNote = {Double-stranded cDNA was prepared from infectious hematopoietic necrosis virus mRNA and cloned into the plasmid vector pUC8.

A coprotein (G-protein) of infectious. Infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are important pathogens of salmon and trout.

An active bivalent DNA vaccine was constructed with the Cited by: Infectious hematopoietic necrosis is caused by infectious hematopoietic necrosis virus (IHNV), a member of the genus Novirhabdovirus and family Rhabdoviridae. Virus strains vary in their pathogenicity. IHNV isolates can be grouped into three genetic types, which are correlated mainly with geographic Size: KB.

Respiratory syncytial virus (RSV) is the leading cause of severe lower respiratory tract illness in newborns and young infants [1, 2].It is increasingly recognized to be an important pathogen in elderly and immunocompromised patients [].No effective treatment is available for RSV-induced disease, and the cost-effectiveness of promising prophylactic antibodies is under Cited by: The DNA vaccine pIHNw-G encodes the glycoprotein of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV).

Vaccine performance in rainbow trout was measured 3, 6, 13, 24, and 25 months after vaccination. At three months all fish vaccinated with μg pIHNw-G had detectable neutralizing antibody (NAb) and they were completely protected from lethal Cited by:   Infectious hematopoietic necrosis virus (IHNV; n = 18) was identified in the Korean national surveillance program between February and Aprilsuggesting that IHNV is a major viral pathogen in cultured salmonids.

By phylogeny analysis, we found that the JRt-Nagano and JRt-Shizuoka groups could each be further subdivided into three distinct by: 2.

In this study, plasmid DNA encoding the glycoproteins of infectious hematopoietic necrosis virus (pcDNA3-IHNV-g), snakehead rhabdovirus (pcDNA3-SHRV-g), or spring viremia of carp virus (pcDNA3-SVCV-g) was injected into the skeletal muscle of rainbow trout fry.

At 30 days post-vaccination, fish were challenged with : John D. Drennan. 1 Introduction. Developing a vaccine from concept to market costs $‐$ million, and takes 5–18 years.

Additionally, it costs an estimated $50‐$ million to construct, equip, and commission a vaccine manufacturing facility, taking on average 7 years, 1, while the lead time to manufacture a vaccine ranges between ‐3 years.

1, 8 To better understand these high. Infectious hematopoietic necrosis virus (IHNV, Rhabdoviridae), is the causative agent of infectious hematopoietic necrosis (IHN), a disease notifiable to the World Organisation for Animal Health, and various countries and trading areas (including the European Union).

IHNV is an economically important pathogen causing clinical disease and mortalities in a wide Cited by: A total of isolates from estuarine and marine environments were evaluated for antiviral activity against infectious hematopoietic necrosis virus (INHV) according to plaque reduction assay.

Among isolates from estuarine environment, (71%) of strains exhibited a 50% plaque reduction of IHNV, including 58 strains (18%) able to reduce Cited by: These include a fish vaccine for infectious hematopoietic necrosis virus licensed inand a vaccine against salmon pancreas disease licensed in A dog cancer immunotherapeutic vaccine for melanoma was licensed originally based upon comparison with historic controls in Cited by: • Infectious Hematopoietic Necrosis Virus Vaccine, DNA, Product Code 17A5.D0, for use in salmonids.

INTERVET INC., U.S. Veterinary License No. A, West Center Road, Elkhorn, NE • Edwardsiella Ictalurii Vaccine, Avirulent Live Culture, Product Codefor use in catfish. The second factor was that there existed an effective vaccine to protect an individual from developing the disease.

The third factor was that so many people became vaccinated that the virus could not spread from a sick individual. This same set of conditions exists for polio. It is Infectious hematopoietic necrosis virus. Infectious hematopoietic necrosis virus listed as IHNV. Infectious hematopoietic necrosis virus - How is Infectious hematopoietic necrosis virus abbreviated.

Detection and identification of Infectious pancreatic necrosis virus (IPNV) and Infectious hematopoietic necrosis virus (IHNV) by.

Infectious Hematopoietic Necrosis Other Names: Oregon Sockeye Salmon Disease, Columbia River Sockeye Disease, Sacramento River Chinook Disease Infectious hematopoietic necrosis (IHN) is a serious viral disease of salmonid fish. @article{osti_, title = {Development of a Vaccine for Bacterial Kidney Disease in Salmon, Annual Report.}, author = {Kaattari, Stephen L}, abstractNote = {Bacterial kidney disease (BRD) has been and remains a chronic contributory problem limiting the productivity of salmon in the Columbia River Basin.

Control of this disease will not come easily, but it would lead to a Author: Stephen L. Kaattari. As a live attenuated vaccine, yellow fever vaccine (YFV) is not routinely performed after allogeneic hematopoietic stem cell transplant (HSCT) despite it being the only efficient preventive therapy.

We retrospectively identified 21 HSCT recipients immunized with YFV at a median of 39 months after HSCT and a median of 33 months after withdrawal Cited by: 9. All inactivated vaccines can be administered safely to persons with altered immunocompetence, whether the vaccine is a killed whole-organism or a recombinant, subunit, split-virus, toxoid, polysaccharide, or polysaccharide protein-conjugate vaccine.

Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic. An enzyme-linked immunosorbent assay (ELISA) with viral culture fluids as capture antigens was performed to detect specific antibodies against infectious hematopoietic necrosis virus (IHNV) from rainbow trout Oncorhynchus mykiss sera.

When using IHNV antigen (IHNV-Ag), ELISA OD values for IHN-survived (IHN-Surv) rainbow trout sera were relatively higher than those for Cited by: WHAT: Scientists have identified three types of vaccine-induced antibodies that can neutralize diverse strains of influenza virus that infect humans.

The discovery will help guide development of a universal influenza vaccine, according to investigators at the National Institute of Allergy and Infectious Diseases (NIAID), and the National Human Genome Research Institute (NHGRI). Varicella vaccine virus has not been found in human milk ().

Although rubella vaccine virus might be excreted in human milk, the virus usually does not infect the infant. If infection does occur, it is well tolerated because the virus is attenuated ().

Inactivated, recombinant, subunit, polysaccharide, and conjugate vaccines, as well as. EPA1 EPA EPA EPA1 EP A1 EP A1 EP A1 EP A EP A EP A EP A EP A EP A EP A1 EP A1 EP A1 Authority EP European Patent Office Prior art keywords characterized vaccine plasmid according vp2 Prior art date Author: Fleiderman Salomón Luis Kriman, Hernandez Miguel Ernesto Reyes, Cayo Patricio Alejandro Oyarzun, Fer.

The safety and genetic stability of V, a novel Venezuelan Equine Encephalitis Virus (VEEV) vaccine based on the investigational VEEV TC strain, was evaluated in mice.

V was generated from infectious DNA, contains a stabilizing mutation in the E glycoprotein, and includes rearrangement of structural genes.

WOA1 PCT/EC/ ECW WOA1 WO A1 WO A1 WO A1 EC W EC W EC W WO A1 WO A1 WO A1 Authority WO WIPO (PCT) Prior art keywords characterized according vaccine vp2 plasmid Prior art date Author: Fleiderman Salomón Luis Kriman, Hernandez Miguel Ernesto Reyes, Cayo Patricio Alejandro Oyarzun, Fer.

Biologic response modifiers (BRMs) are substances that interact with and modify the host immune system.

BRMs that dampen the immune system are used to treat conditions such as juvenile idiopathic arthritis, psoriatic arthritis, or inflammatory bowel disease and often in combination with other immunosuppressive agents, such as methotrexate and by:   Immunogenicity and Safety of Subunit Plague Vaccine The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S. Federal Government. infectious pancreatic necrosis virus in Scottish salmon farms from to An annual increase in the prevalence of this virus was found in saltwater (10%) and freshwater sites (2% to 3%), with a much faster increase (%) in Shetland’s freshwa-ter sites.

No significant increase in the virus was detected in the.The development of genetically modified 'whole' tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors. In the present study, we have used a disabled infectious single cycle-herpes simplex virus 2 (DISC-HSV-2) vector constructed to express cytokine or marker genes upon by: A vaccine is the most important biopharmaceutical used for infectious disease prevention.

It usually contains a biological agent that resembles a pathogen and is usually made from inactivated microbes, live attenuated microbes, toxoids (toxins), and or Cited by: 2.